laser scanning engine Search Results


infrared scanning laser fundus photography spectralis hra + oct  (heidelberg engineering)
90
heidelberg engineering infrared scanning laser fundus photography spectralis hra + oct
Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and <t>fundus</t> <t>photography,</t> during which <t>infrared</t> fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.
Infrared Scanning Laser Fundus Photography Spectralis Hra + Oct, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/laser+scanning+engine/infrared+scanning+laser+fundus+photography+spectralis+hra+++oct/pmc06167562-51-0-9
Average 90 stars, based on 1 article reviews
infrared scanning laser fundus photography spectralis hra + oct - by Bioz Stars, 2026-09
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scanning laser ophthalmoscopy and spectral domains of optical coherence tomography  (heidelberg engineering)
90
heidelberg engineering scanning laser ophthalmoscopy and spectral domains of optical coherence tomography
Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and <t>fundus</t> <t>photography,</t> during which <t>infrared</t> fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.
Scanning Laser Ophthalmoscopy And Spectral Domains Of Optical Coherence Tomography, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/laser+scanning+engine/scanning+laser+ophthalmoscopy+and+spectral+domains+of+optical+coherence+tomography/pm36976356-50-25-37
Average 90 stars, based on 1 article reviews
scanning laser ophthalmoscopy and spectral domains of optical coherence tomography - by Bioz Stars, 2026-09
90/100 stars
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confocal-scanning laser fundus autofluorescence (faf, heidelberg engineering, heidelberg, germany)  (heidelberg engineering)
90
heidelberg engineering confocal-scanning laser fundus autofluorescence (faf, heidelberg engineering, heidelberg, germany)
Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and <t>fundus</t> <t>photography,</t> during which <t>infrared</t> fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.
Confocal Scanning Laser Fundus Autofluorescence (Faf, Heidelberg Engineering, Heidelberg, Germany), supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
confocal-scanning laser fundus autofluorescence (faf, heidelberg engineering, heidelberg, germany) - by Bioz Stars, 2026-09
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laser barcode scan engine  (DATALOGIC Mobile CEC)
90
DATALOGIC Mobile CEC laser barcode scan engine
Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and <t>fundus</t> <t>photography,</t> during which <t>infrared</t> fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.
Laser Barcode Scan Engine, supplied by DATALOGIC Mobile CEC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/laser+scanning+engine/laser+barcode+scan+engine/us10222979-64-11-17
Average 90 stars, based on 1 article reviews
laser barcode scan engine - by Bioz Stars, 2026-09
90/100 stars
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scanning laser ophthalmoscope (spectralis hra+oct  (heidelberg engineering)
90
heidelberg engineering scanning laser ophthalmoscope (spectralis hra+oct
Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and <t>fundus</t> <t>photography,</t> during which <t>infrared</t> fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.
Scanning Laser Ophthalmoscope (Spectralis Hra+Oct, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/laser+scanning+engine/scanning+laser+ophthalmoscope/pmc03408752-386-8-13
Average 90 stars, based on 1 article reviews
scanning laser ophthalmoscope (spectralis hra+oct - by Bioz Stars, 2026-09
90/100 stars
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confocal scanning laser ophthalmoscope with 488-nm excitation spectralis hra+oct  (heidelberg engineering)
90
heidelberg engineering confocal scanning laser ophthalmoscope with 488-nm excitation spectralis hra+oct
Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and <t>fundus</t> <t>photography,</t> during which <t>infrared</t> fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.
Confocal Scanning Laser Ophthalmoscope With 488 Nm Excitation Spectralis Hra+Oct, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
confocal scanning laser ophthalmoscope with 488-nm excitation spectralis hra+oct - by Bioz Stars, 2026-09
90/100 stars
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infrared scanning laser ophthalmoscopic (slo) images  (heidelberg engineering)
90
heidelberg engineering infrared scanning laser ophthalmoscopic (slo) images
Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and <t>fundus</t> <t>photography,</t> during which <t>infrared</t> fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.
Infrared Scanning Laser Ophthalmoscopic (Slo) Images, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/laser+scanning+engine/scanning+laser+ophthalmoscopy++slo/pmc11508322-77-7-14
Average 90 stars, based on 1 article reviews
infrared scanning laser ophthalmoscopic (slo) images - by Bioz Stars, 2026-09
90/100 stars
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hrt ii laser scanning confocal microscope  (heidelberg engineering)
90
heidelberg engineering hrt ii laser scanning confocal microscope
Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and <t>fundus</t> <t>photography,</t> during which <t>infrared</t> fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.
Hrt Ii Laser Scanning Confocal Microscope, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/laser+scanning+engine/hrt+ii+laser+scanning+confocal+microscope/pmc02752303-171-6-12
Average 90 stars, based on 1 article reviews
hrt ii laser scanning confocal microscope - by Bioz Stars, 2026-09
90/100 stars
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scanning laser doppler flowmetry heidelberg retina flowmeter  (heidelberg engineering)
90
heidelberg engineering scanning laser doppler flowmetry heidelberg retina flowmeter
Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and <t>fundus</t> <t>photography,</t> during which <t>infrared</t> fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.
Scanning Laser Doppler Flowmetry Heidelberg Retina Flowmeter, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/laser+scanning+engine/scanning+laser+doppler+flowmetry+at+heidelberg+retina+flowmeter/10__1161_slash_hypertensionaha__121__17954-115-5-12
Average 90 stars, based on 1 article reviews
scanning laser doppler flowmetry heidelberg retina flowmeter - by Bioz Stars, 2026-09
90/100 stars
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spectral-domain optical coherence tomography spectralis optical coherence tomography/scanning laser ophthalmoscopy  (heidelberg engineering)
90
heidelberg engineering spectral-domain optical coherence tomography spectralis optical coherence tomography/scanning laser ophthalmoscopy
Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and <t>fundus</t> <t>photography,</t> during which <t>infrared</t> fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.
Spectral Domain Optical Coherence Tomography Spectralis Optical Coherence Tomography/Scanning Laser Ophthalmoscopy, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
spectral-domain optical coherence tomography spectralis optical coherence tomography/scanning laser ophthalmoscopy - by Bioz Stars, 2026-09
90/100 stars
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retinal tomograph rostock corneal module confocal laser scanning microscope  (heidelberg engineering)
90
heidelberg engineering retinal tomograph rostock corneal module confocal laser scanning microscope
Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and <t>fundus</t> <t>photography,</t> during which <t>infrared</t> fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.
Retinal Tomograph Rostock Corneal Module Confocal Laser Scanning Microscope, supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/laser+scanning+engine/retinal+tomograph+rostock+corneal+module+confocal+laser+scanning+microscope/pmc10942905-94-10-21
Average 90 stars, based on 1 article reviews
retinal tomograph rostock corneal module confocal laser scanning microscope - by Bioz Stars, 2026-09
90/100 stars
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central infrared scanning laser ophthalmoscopy image (ir815nm, spectralis heidelberg retina angiograph 2)  (heidelberg engineering)
90
heidelberg engineering central infrared scanning laser ophthalmoscopy image (ir815nm, spectralis heidelberg retina angiograph 2)
Summary of the methodology. Step 1: Extraction of raw images from each imaging modality at each visit. Note that images vary in field of view due to use of different imaging modalities. Step 2: Pre-processing of images as described in Ly et al. Images are registered, background corrected, and contrast enhanced. Step 3.a: Clustering analysis using pattern recognition is performed across the three images yielding a single multispectral image where each color represents a distinct spectral theme class. Step 3.b Spectral theme classes assigned as drusen/not drusen using reference color fundus photograph annotated for drusen by clinical experts. Step 4: Identification of spectral theme classes attributed to drusen from the pseudocolored image. (A): Spectral theme classes identified as drusen were thresholded from all other theme classes in the pseudocolored image and (B) Drusen spectral theme classes were merged to create a duochrome image. Step 5: Quantification of drusen. Total number of pixels attributed to drusen were quantified from duochrome images at each visit and drusen change calculated as a percentage difference between the two visits. CFP: Color fund photograph, FAF: fundus autofluorescence, IR: infrared, OG: green scanning laser <t>ophthalmoscopy</t> images.
Central Infrared Scanning Laser Ophthalmoscopy Image (Ir815nm, Spectralis Heidelberg Retina Angiograph 2), supplied by heidelberg engineering, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
central infrared scanning laser ophthalmoscopy image (ir815nm, spectralis heidelberg retina angiograph 2) - by Bioz Stars, 2026-09
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Image Search Results


Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and fundus photography, during which infrared fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.

Journal: Journal of Ophthalmology

Article Title: Retinal Vessel Diameter Changes in Relation to Dark Adaptation and Acute Hyperglycemia

doi: 10.1155/2018/7064359

Figure Lengend Snippet: Retinal vessel diameter data indexed to baseline (triangles: arteries and squares: veins) in 14 patients with type 2 diabetes who were fasting (glycemia 7.6 ± 1.7 mM) and adapted to room light at baseline (0 minutes). This was followed by a cycle of dark adaptation and fundus photography, during which infrared fundus photography, which had also been made at baseline, was repeated twice. Daylight was reintroduced after 40 minutes and then, 5 min later, participants ingested 75 g of glucose dissolved in water. After 70 more minutes when glycemia had increased to 15.7 ± 4.2 mM, infrared photographs were recorded in daylight, after which a second round of dark adaptation and photography was reinitiated. PG, plasma glucose; OGTT, oral glucose tolerance test; IR, infrared. Values greater than 1 indicate vessel dilation and values lower than 1 indicate vessel contraction. One-sided error bars indicate 1 standard deviation. Asterisk ∗ 1 indicates P < 0.05 compared to the nearest predark adaptation baseline, fasting, or hyperglycemic. Asterisk ∗ 2 indicates P < 0.05 for a given time point during the second (hyperglycemic) dark adaptation cycle compared to the first (fasting) dark adaptation cycle.

Article Snippet: Infrared scanning laser fundus photography (Spectralis HRA + OCT, Heidelberg Engineering, Heidelberg, Germany) was made over a 55-degree angle centered on the optic disc with a nominal resolution of 768 × 768 pixels.

Techniques: Clinical Proteomics, Standard Deviation

Summary of the methodology. Step 1: Extraction of raw images from each imaging modality at each visit. Note that images vary in field of view due to use of different imaging modalities. Step 2: Pre-processing of images as described in Ly et al. Images are registered, background corrected, and contrast enhanced. Step 3.a: Clustering analysis using pattern recognition is performed across the three images yielding a single multispectral image where each color represents a distinct spectral theme class. Step 3.b Spectral theme classes assigned as drusen/not drusen using reference color fundus photograph annotated for drusen by clinical experts. Step 4: Identification of spectral theme classes attributed to drusen from the pseudocolored image. (A): Spectral theme classes identified as drusen were thresholded from all other theme classes in the pseudocolored image and (B) Drusen spectral theme classes were merged to create a duochrome image. Step 5: Quantification of drusen. Total number of pixels attributed to drusen were quantified from duochrome images at each visit and drusen change calculated as a percentage difference between the two visits. CFP: Color fund photograph, FAF: fundus autofluorescence, IR: infrared, OG: green scanning laser ophthalmoscopy images.

Journal: Scientific Reports

Article Title: Multispectral pattern recognition measures change in drusen area in age-related macular degeneration with high congruency to expert graders

doi: 10.1038/s41598-022-11070-6

Figure Lengend Snippet: Summary of the methodology. Step 1: Extraction of raw images from each imaging modality at each visit. Note that images vary in field of view due to use of different imaging modalities. Step 2: Pre-processing of images as described in Ly et al. Images are registered, background corrected, and contrast enhanced. Step 3.a: Clustering analysis using pattern recognition is performed across the three images yielding a single multispectral image where each color represents a distinct spectral theme class. Step 3.b Spectral theme classes assigned as drusen/not drusen using reference color fundus photograph annotated for drusen by clinical experts. Step 4: Identification of spectral theme classes attributed to drusen from the pseudocolored image. (A): Spectral theme classes identified as drusen were thresholded from all other theme classes in the pseudocolored image and (B) Drusen spectral theme classes were merged to create a duochrome image. Step 5: Quantification of drusen. Total number of pixels attributed to drusen were quantified from duochrome images at each visit and drusen change calculated as a percentage difference between the two visits. CFP: Color fund photograph, FAF: fundus autofluorescence, IR: infrared, OG: green scanning laser ophthalmoscopy images.

Article Snippet: Participants also required the following images accessible in their patient file from each appointment: a central 45 degree color fundus photograph (Kowa WX 3D Nonmydriatic retinal camera; Kowa, Nagoya, Japan), a fundus autofluorescence image (FAF, Optos Panoramic 200Tx; Optos, Dunfermline, UK), a green scanning laser ophthalmoscopy image (Green532nm, Optos Panoramic 200Tx), a central infrared scanning laser ophthalmoscopy image (IR815nm, Spectralis Heidelberg Retina Angiograph 2; Heidelberg Engineering, Heidelberg, Germany) and a macular SD-OCT cube scan (Cirrus 6000; Zeiss, Carl Zeiss Meditec.

Techniques: Extraction, Imaging

( A ) Image alignment was performed on FAF, IR815nm and Green532nm scanning laser ophthalmoscopy using ir-tweak such that the eight blood vessel bifurcation reference points were matched to the CFP. ( B ): Images were processed using ImageJ to ensure useful classification of retinal architecture: background corrected by subtracting the Gaussian blurred image from the original, contrast enhanced and masked to remove areas beyond the macula.

Journal: Scientific Reports

Article Title: Multispectral pattern recognition measures change in drusen area in age-related macular degeneration with high congruency to expert graders

doi: 10.1038/s41598-022-11070-6

Figure Lengend Snippet: ( A ) Image alignment was performed on FAF, IR815nm and Green532nm scanning laser ophthalmoscopy using ir-tweak such that the eight blood vessel bifurcation reference points were matched to the CFP. ( B ): Images were processed using ImageJ to ensure useful classification of retinal architecture: background corrected by subtracting the Gaussian blurred image from the original, contrast enhanced and masked to remove areas beyond the macula.

Article Snippet: Participants also required the following images accessible in their patient file from each appointment: a central 45 degree color fundus photograph (Kowa WX 3D Nonmydriatic retinal camera; Kowa, Nagoya, Japan), a fundus autofluorescence image (FAF, Optos Panoramic 200Tx; Optos, Dunfermline, UK), a green scanning laser ophthalmoscopy image (Green532nm, Optos Panoramic 200Tx), a central infrared scanning laser ophthalmoscopy image (IR815nm, Spectralis Heidelberg Retina Angiograph 2; Heidelberg Engineering, Heidelberg, Germany) and a macular SD-OCT cube scan (Cirrus 6000; Zeiss, Carl Zeiss Meditec.

Techniques: